Characterization of 14-3-3-ζ Interactions with Integrin Tails
نویسندگان
چکیده
منابع مشابه
Modulators of 14-3-3 Protein-Protein Interactions.
Direct interactions between proteins are essential for the regulation of their functions in biological pathways. Targeting the complex network of protein-protein interactions (PPIs) has now been widely recognized as an attractive means to therapeutically intervene in disease states. Even though this is a challenging endeavor and PPIs have long been regarded as "undruggable" targets, the last tw...
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Proteins that interact with 14-3-3 isoforms are involved in regulation of the cell cycle, intracellular trafficking/targeting, signal transduction, cytoskeletal structure and transcription. Recent novel roles for 14-3-3 isoforms include nuclear trafficking the direct interaction with cruciform DNA and with a number of receptors, small G-proteins and their regulators. Recent findings also show t...
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The 14-3-3 family of proteins function as small adaptors that facilitate a diverse array of cellular processes by mediating specific protein interactions. One such process is the DNA damage checkpoint, where these proteins prevent inappropriate activation of cyclin-dependent kinases. The filamentous fungus Aspergillus nidulans possesses a highly conserved 14-3-3 homologue (artA) that may functi...
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UNLABELLED The parasite Cryptosporidium parvum has three 14-3-3 proteins: Cp14ε, Cp14a and Cp14b, with only Cp14ε similar to human 14-3-3 proteins in sequence, peptide-binding properties and structure. Structurally, Cp14a features the classical 14-3-3 dimer but with a uniquely wide pocket and a disoriented RRY triad potentially incapable of binding phosphopeptides. The Cp14b protein deviates fr...
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Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP/protein kinase A (PKA)-regulated chloride channel whose phosphorylation controls anion secretion across epithelial cell apical membranes. We examined the hypothesis that cAMP/PKA stimulation regulates CFTR biogenesis posttranslationally, based on predicted 14-3-3 binding motifs within CFTR and forskolin-induced CFTR expression...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2013
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2013.05.024